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1

Kaskaden-Radikalreaktionen von Isocyaniden: eine zweite Generation der Synthese von (20S)-Camptothecin, Topotecan, Irinotecan und GI-147211C

Prof. Dr. Dennis P. Curran, Sung-Bo Ko, Dr. Hubert Josien

Journal:

Angewandte Chemie

Year:

1995

File:

PDF, 390 KB

1995

2

Cascade Radical Reactions of Isonitriles: A Second-Generation Synthesis of (20S)-Camptothecin, Topotecan, Irinotecan, and GI-147211C

Prof. Dennis P. Curran, Sung-Bo Ko, Dr. Hubert Josien

Journal:

Angewandte Chemie International Edition

Year:

1996

Language:

english

File:

PDF, 242 KB

english, 1996

3

‘Song of Life’: music therapy in terminally ill patients with cancer

Warth, Marco, Kessler, Jens, van Kampen, Josien, Ditzen, Beate, Bardenheuer, Hubert J

Journal:

BMJ Supportive & Palliative Care

Year:

2018

Language:

english

File:

PDF, 243 KB

english, 2018

4

A General Synthetic Approach to the (20S)-Camptothecin Family of Antitumor Agents by a Regiocontrolled Cascade Radical Cyclization of Aryl Isonitriles

Hubert Josien, Sung-Bo Ko, David Bom, Dennis P. Curran

Journal:

Chemistry - A European Journal

Year:

1998

Language:

english

File:

PDF, 331 KB

english, 1998

5

ChemInform Abstract: Design of Constrained Analogues of Amino Acids and Their Incorporation in the Sequence of Substance P

Mimoun Ayoub, Alie Brunissen, Hubert Josien, Albert Loffet, Gerard Chassaing, Solange Lavielle

Journal:

Year:

1999

File:

PDF, 25 KB

1999

6

ChemInform Abstract: The Cascade Radical Annulation Approach to New Analogues of Camptothecins: Combinatorial Synthesis of Silatecans and Homosilatecans

Dennis P. Curran, Hubert Josien, David Bom, Ana E. Gabarda, Wu Du

Journal:

Year:

2001

File:

PDF, 25 KB

2001

7

ChemInform Abstract: Synthesis of Mono- and Difluoronaphthoic Acids.

Jayaram R. Tagat, Stuart W. McCombie, Dennis V. Nazareno, Craig D. Boyle, Joseph A. Kozlowski, Samuel Chackalamannil, Hubert Josien, Yuguang Wang, Guowei Zhou

Journal:

Year:

2002

File:

PDF, 31 KB

2002

8

Tandem radical reactions of isonitriles with 2-pyridonyl and other aryl radicals: Scope and limitations, and a first generation synthesis of (±)-camptothecin

Dennis P. Curran, Hui Liu, Hubert Josien, Sung-Bo Ko

Journal:

Year:

1996

Language:

english

File:

PDF, 1.32 MB

english, 1996

9

Asymmetric synthesis of L-diphenylalanine and L-9-fluorenylglycine via room temperature alkylations of a sultam-derived glycine imine

Hubert Josien, Arnaud Martin, Gérard Chassaing

Journal:

Tetrahedron Letters

Year:

1991

Language:

english

File:

PDF, 287 KB

english, 1991

10

Selective N-functionalization of 6-substituted-2-pyridones

Hui Liu, Sung-Bo Ko, Hubert Josien, Dennis P. Curran

Journal:

Tetrahedron Letters

Year:

1995

Language:

english

File:

PDF, 255 KB

english, 1995

11

Novel orally active morpholine N-arylsulfonamides γ-secretase inhibitors with low CYP 3A4 liability

Hubert Josien, Thomas Bara, Murali Rajagopalan, John W. Clader, William J. Greenlee, Leonard Favreau, Lynn A. Hyde, Amin A. Nomeir, Eric M. Parker, Lixin Song, Lili Zhang, Qi Zhang

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 1.22 MB

english, 2009

12

Design and synthesis of tricyclic sulfones as γ-secretase inhibitors with greatly reduced Notch toxicity

Ruo Xu, David Cole, Ted Asberom, Tom Bara, Chad Bennett, Duane A. Burnett, John Clader, Martin Domalski, William Greenlee, Lynn Hyde, Hubert Josien, Hongmei Li, Mark McBriar, Brian McKittrick, Andrew

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 664 KB

english, 2010

13

Asymmetric synthesis of the diastereoisomers of L-1-indanylglycine and L-1-benz[f]indanylglycine, χ1,χ2-constrained side-chain derivatives of L-phenylalanine and L-2-naphthylalanine

Hubert Josien, Gérard Chassaing

Journal:

Tetrahedron: Asymmetry

Year:

1992

Language:

english

File:

PDF, 323 KB

english, 1992

14

Tetrahydroquinoline sulfonamides as γ-secretase inhibitors

Theodros Asberom, Thomas A. Bara, John W. Clader, William J. Greenlee, Henry S. Guzik, Hubert B. Josien, Wei Li, Eric M. Parker, Dmitri A. Pissarnitski, Lixin Song, Lili Zhang, Zhiqiang Zhao

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 151 KB

english, 2007

15

Discovery of γ-secretase inhibitors efficacious in a transgenic animal model of Alzheimer’s disease

Theodros Asberom, Zhiqiang Zhao, Thomas A. Bara, John W. Clader, William J. Greenlee, Lynn A. Hyde, Hubert B. Josien, Wei Li, Andrew T. McPhail, Amin A. Nomeir, Eric M. Parker, Murali Rajagopalan, Lix

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 263 KB

english, 2007

16

Small conformationally restricted piperidine N-arylsulfonamides as orally active γ-secretase inhibitors

Hubert Josien, Thomas Bara, Murali Rajagopalan, Theodros Asberom, John W. Clader, Leonard Favreau, William J. Greenlee, Lynn A. Hyde, Amin A. Nomeir, Eric M. Parker, Dmitri A. Pissarnitski, Lixin Song

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 209 KB

english, 2007

17

Discovery of 2,4,6-trisubstituted N-arylsulfonyl piperidines as γ-secretase inhibitors

Hongmei Li, Theodros Asberom, Thomas A. Bara, John W. Clader, William J. Greenlee, Hubert B. Josien, Mark D. McBriar, Amin Nomeir, Dmitri A. Pissarnitski, Murali Rajagopalan, Ruo Xu, Zhiqiang Zhao, Li

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 410 KB

english, 2007

18

(2-chloro-2-nitroethenyl)benzenes as synthons: a general method for the preparation of 2,3-dihydro- 2-nitro-3-phenyl-4H-furo [3,2-c] [1]benzopyran-4-ones and 3-phenyl-4H-furo[3,2-c][1]benzopyran-4-ones

Daniel Dauzonne, Hubert Josien, Pierre Demerseman

Journal:

Year:

1990

Language:

english

File:

PDF, 640 KB

english, 1990

19

Metabolic stabilization of benzylidene ketal M2 muscarinic receptor antagonists via halonaphthoic acid substitution

Craig D. Boyle, Samuel Chackalamannil, John W. Clader, William J. Greenlee, Hubert B. Josien, James J. Kaminski, Joseph A. Kozlowski, Stuart W. McCombie, Dennis V. Nazareno, Jayaram R. Tagat, Yuguang

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 129 KB

english, 2001

20

7-Silylcamptothecins (silatecans): A new family of camptothecin antitumor agents

Hubert Josien, David Bom, Dennis P. Curran, Yu-Huang Zheng, Ting-Chao Chou

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 390 KB

english, 1997

21

Tachykinin NK-1 receptor probed with constrained analogues of substance P

Sandrine Sagan, Hubert Josien, Philippe Karoyan, Alié Brunissen, Gérard Chassaing, Solange Lavielle

Journal:

Bioorganic & Medicinal Chemistry

Year:

1996

Language:

english

File:

PDF, 1.08 MB

english, 1996

22

SAR of tricyclic sulfones as γ-secretase inhibitors

Ruo Xu, David Cole, Ted Asberom, Tom Bara, Chad Bennett, Duane A. Burnett, John Clader, Martin Domalski, William J. Greenlee, Lynn Hyde, Hubert Josien, HongMei Li, Mark McBriar, Brian McKittrick, Dmit

Journal:

Science China Chemistry

Year:

2011

Language:

english

File:

PDF, 738 KB

english, 2011

23

2,6-Disubstituted N-arylsulfonyl piperidines as γ-secretase inhibitors

Dmitri A. Pissarnitski, Theodros Asberom, Thomas A. Bara, Alex V. Buevich, John W. Clader, William J. Greenlee, Henry S. Guzik, Hubert B. Josien, Wei Li, Michael McEwan, Brian A. McKittrick, Terry L.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 238 KB

english, 2007

24

Synthesis of (S)-mappicine and mappicine ketone via radical cascade reaction of isonitriles

Hubert Josien, Dennis P. Curran

Journal:

Year:

1997

Language:

english

File:

PDF, 565 KB

english, 1997

25

The Cascade Radical Annulation Approach to New Analogues of Camptothecins: Combinatorial Synthesis of Silatecans and Homosilatecans

DENNIS P. CURRAN, HUBERT JOSIEN, DAVID BOM, ANA E. GABARDA, WU DU

Journal:

Annals of the New York Academy of Sciences

Year:

2000

Language:

english

File:

PDF, 6.95 MB

english, 2000

26

Discovery of SCH 900229, a Potent Presenilin 1 Selective γ-Secretase Inhibitor for the Treatment of Alzheimer’s Disease

Wu, Wen-Lian, Domalski, Martin, Burnett, Duane A., Josien, Hubert, Bara, Thomas, Rajagopalan, Murali, Xu, Ruo, Clader, John, Greenlee, William J., Brunskill, Andrew, Hyde, Lynn A., Del Vecchio, Robert

Journal:

ACS Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 315 KB

english, 2012

27

The discovery of fused oxadiazepines as gamma secretase modulators for treatment of Alzheimer’s disease

Li, Hongmei, Qin, Jun, Dhondi, Pawan, Zhou, Wei, Vicarel, Monica, Bara, Thomas, Cole, David, Josien, Hubert, Pissarnitski, Dmitri, Zhu, Zhaoning, Palani, Anandan, Aslanian, Robert, Clader, John, Czarn

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 1.85 MB

english, 2013

28

Second Generation Synthesis of (20S)-Camptothecin and Derivatives via a Cascade Radical Reaction

DENNIS P. CURRAN, HUBERT JOSIEN, SUNG-BO KO

Journal:

Annals of the New York Academy of Sciences

Year:

1996

Language:

english

File:

PDF, 78 KB

english, 1996

29

Interleukin-22 binding protein (IL-22BP) is constitutively expressed by a subset of conventional dendritic cells and is strongly induced by retinoic acid

Martin, J CJ, Bériou, G, Heslan, M, Chauvin, C, Utriainen, L, Aumeunier, A, Scott, C L, Mowat, A, Cerovic, V, Houston, S A, Leboeuf, M, Hubert, F X, Hémont, C, Merad, M, Milling, S, Josien, R

Journal:

Mucosal Immunology

Year:

2014

Language:

english

File:

PDF, 909 KB

english, 2014

30

Concise Formation of 4-Benzyl Piperidines and Related Derivatives Using a Suzuki Protocol

Vice, Susan, Bara, Tom, Bauer, Annette, Evans, C. Anderson, Ford, Jennifer, Josien, Hubert, McCombie, Stuart, Miller, Michael, Nazareno, Dennis, Palani, Anandan, Tagat, Jay

Journal:

Journal of Organic Chemistry

Year:

2001

Language:

english

File:

PDF, 101 KB

english, 2001

31

Synthesis, SAR, and Biological Evaluation of Oximino-Piperidino-Piperidine Amides. 1. Orally Bioavailable CCR5 Receptor Antagonists with Potent Anti-HIV Activity

Palani, Anandan, Shapiro, Sherry, Josien, Hubert, Bara, Thomas, Clader, John W., Greenlee, William J., Cox, Kathleen, Strizki, Julie M., Baroudy, Bahige M.

Journal:

Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 194 KB

english, 2002

32

Design and Synthesis of Side-Chain Conformationally Restricted Phenylalanines and Their Use for Structure-Activity Studies on Tachykinin NK-1 Receptor

Josien, Hubert, Lavielle, Solange, Brunissen, Alie, Saffroy, Monique, Torrens, Yvette, Beaujouan, Jean-Claude, Glowinski, Jacques, Chassaing, Gerard

Journal:

Journal of Medicinal Chemistry

Year:

1994

Language:

english

File:

PDF, 2.31 MB

english, 1994

33

P4-364 Rapid in-vivo assessment of therapeutic window of two γ-secretase inhibitors in transgenic CRND8 mice

Hyde, Lynn A., Manfra, Denise, McHugh, Nansie A., Zhang, Qi, Engstrom, Laura, Pinzon-Ortiz, Maria C., Chen, Joseph, Josien, Hubert, Clader, John, Zhang, Lili, Parker, Eric M., Higgins, Guy A.

Journal:

Neurobiology of Aging

Year:

2004

Language:

english

File:

PDF, 327 KB

english, 2004

34

Structure activity relationship studies of tricyclic bispyran sulfone γ-secretase inhibitors

Wu, Wen-Lian, Asberom, Theodros, Bara, Thomas, Bennett, Chad, Burnett, Duane A., Clader, John, Domalski, Martin, Greenlee, William J., Josien, Hubert, McBriar, Mark, Rajagopalan, Murali, Vicarel, Moni

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 966 KB

english, 2013

35

Efficient synthesis and reaction pathway studies of novel fused morpholine oxadiazolines for use as gamma secretase modulators

Huang, Xianhai, Pissarnitski, Dmitri, Li, Hongmei, Asberom, Theodros, Josien, Hubert, Zhu, Xiaohong, Vicarel, Monica, Zhao, Zhiqiang, Rajagopalan, Murali, Palani, Anandan, Aslanian, Robert, Zhu, Zhaon

Journal:

Tetrahedron Letters

Year:

2012

Language:

english

File:

PDF, 588 KB

english, 2012

36

Nouvelle approche thérapeutique potentielle des ostéosarcomes par immunothérapie active utilisant une sous-population de cellules dendritiques spléniques chez le rat

Wittrant, Y., Chauvin, C., Lamoureux, F., Trinite, B., Hubert, F., Heymann, D., Josien, R., Redini, F.

Journal:

Year:

2006

Language:

french

File:

PDF, 78 KB

french, 2006

37

Identification of Presenilin 1-Selective γ-Secretase Inhibitors with Reconstituted γ-Secretase Complexes

Lee, Julie, Song, Lixin, Terracina, Giuseppe, Bara, Thomas, Josien, Hubert, Asberom, Theodros, Sasikumar, Thavalakulamgar K., Burnett, Duane A., Clader, John, Parker, Eric M., Zhang, Lili

Journal:

Year:

2011

Language:

english

File:

PDF, 1.85 MB

english, 2011

38

Synthesis of Mono- and Difluoronaphthoic Acids

Tagat, Jayaram R., McCombie, Stuart W., Nazareno, Dennis V., Boyle, Craig D., Kozlowski, Joseph A., Chackalamannil, Samuel, Josien, Hubert, Wang, Yuguang, Zhou, Guowei

Journal:

Journal of Organic Chemistry

Year:

2002

Language:

english

File:

PDF, 103 KB

english, 2002

39

Dominant Tolerance to Kidney Allografts Induced by Anti-Donor MHC Class II Antibodies: Cooperation between T and Non-T CD103+ Cells

Degauque, N., Lair, D., Dupont, A., Moreau, A., Roussey, G., Moizant, F., Hubert, F. X., Louvet, C., Hill, M., Haspot, F., Josien, R., Usal, C., Vanhove, B., Soulillou, J. P., Brouard, S.

Journal:

The Journal of Immunology

Year:

2006

Language:

english

File:

PDF, 771 KB

english, 2006

40

Differential Control of T Regulatory Cell Proliferation and Suppressive Activity by Mature Plasmacytoid versus Conventional Spleen Dendritic Cells

Ouabed, A., Hubert, F.-X., Chabannes, D., Gautreau, L., Heslan, M., Josien, R.

Journal:

The Journal of Immunology

Year:

2008

Language:

english

File:

PDF, 595 KB

english, 2008

41

Two Phenotypically Distinct Subsets of Spleen Dendritic Cells in Rats Exhibit Different Cytokine Production and T Cell Stimulatory Activity

Voisine, C., Hubert, F.-X., Trinite, B., Heslan, M., Josien, R.

Journal:

The Journal of Immunology

Year:

2002

Language:

english

File:

PDF, 239 KB

english, 2002

42

Fms-Like Tyrosine Kinase 3 Ligand Recruits Plasmacytoid Dendritic Cells to the Brain

Curtin, J. F., King, G. D., Barcia, C., Liu, C., Hubert, F. X., Guillonneau, C., Josien, R., Anegon, I., Lowenstein, P. R., Castro, M. G.

Journal:

The Journal of Immunology

Year:

2006

Language:

english

File:

PDF, 1.30 MB

english, 2006

43

Differential Pattern Recognition Receptor Expression but Stereotyped Responsiveness in Rat Spleen Dendritic Cell Subsets

Hubert, F.-X., Voisine, C., Louvet, C., Heslan, J.-M., Ouabed, A., Heslan, M., Josien, R.

Journal:

The Journal of Immunology

Year:

2006

Language:

english

File:

PDF, 651 KB

english, 2006

44

Killer Dendritic Cells Link Innate and Adaptive Immunity against Established Osteosarcoma in Rats

Chauvin, C., Philippeau, J.-M., Hemont, C., Hubert, F.-X., Wittrant, Y., Lamoureux, F., Trinite, B., Heymann, D., Redini, F., Josien, R.

Journal:

Cancer Research

Year:

2008

Language:

english

File:

PDF, 572 KB

english, 2008

45

Rat Plasmacytoid Dendritic Cells Are an Abundant Subset of MHC Class II+ CD4+CD11b-OX62- and Type I IFN-Producing Cells That Exhibit Selective Expression of Toll-Like Receptors 7 and 9 and Strong Responsiveness to CpG

Hubert, F.-X., Voisine, C., Louvet, C., Heslan, M., Josien, R.

Journal:

The Journal of Immunology

Year:

2004

Language:

english

File:

PDF, 849 KB

english, 2004

46

A General Synthesis of 1-Nitro-2-phenyl-4-oxospiro[2.5]octanes

Dauzonne, Daniel, Josien, Hubert, Demerseman, Pierre

Journal:

Year:

1992

File:

PDF, 535 KB

1992

47

Discovery of a novel, potent spirocyclic series of γ-secretase inhibitors

Zhao, Zhiqiang, Pissarnitski, Dmitri A, Josien, Hubert, Wu, Wen-Lian, Xu, Ruo, Li, Hongmei, Clader, John, Burnett, Duane A., Terracina, Giuseppe, Hyde, Lynn, Lee, Julee, Song, Lixin, Zhang, Lili

Journal:

Journal of Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 519 KB

english, 2015

48

Substituted 4-morpholine N-arylsulfonamides as γ-secretase inhibitors

Zhao, Zhiqiang, Pissarnitski, Dmitri A., Josien, Hubert B., Bara, Thomas A., Clader, John W., Li, Hongmei, McBriar, Mark D., Rajagopalan, Murali, Xu, Ruo, Terracina, Giuseppe, Hyde, Lynn, Song, Lixin,

Journal:

European Journal of Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 734 KB

english, 2016

49

Design and Synthesis of Novel, Selective GPR40 AgoPAMs

Plummer, Christopher W., Clements, Matthew J., Chen, Helen, Rajagopalan, Murali, Josien, Hubert, Hagmann, William K., Miller, Michael, Trujillo, Maria E., Kirkland, Melissa, Kosinski, Daniel, Mane, Jo

Journal:

ACS Medicinal Chemistry Letters

Year:

2017

Language:

english

File:

PDF, 528 KB

english, 2017

50

Topographic analysis of the S7 binding subsite of the tachykinin neurokinin-1 receptor

Josien, Hubert, Convert, Odile, Berlose, Jean-Philippe, Sagan, Sandrine, Brunissen, Alié, Lavielle, Solange, Chassaing, Gérard

Journal:

Year:

1998

Language:

english

File:

PDF, 1.19 MB

english, 1998